The Artificial Pancreas Is Here

From Scientific American:

Researchers have been working to make things easier for patients by integrating and automating the steps in the process. The end result—the artificial pancreas—is a system that can figure out how much insulin the body needs in near real time and then deliver that amount on its own. “The artificial pancreas will allow us to live a near-normal life until there is a cure,” says Kelly Dunkling Reilly, a registered nurse and certified diabetes educator who was a subject in a recent clinical trial of Boston-based Beta Bionics’s iLet pancreas. “For the first time in my 24 years with diabetes, I was able to exercise whenever I wanted and work with my patients without the constant fear of hypoglycemia.” After more than a decade in development, several artificial pancreas projects are moving into the final stages before they become widely available.

1. In June medical device maker Medtronic filed a premarket-approval application to the Food and Drug Administration for a “hybrid closed loop”—an insulin pump that analyzes data from a continuous glucose monitor and automatically adjusts insulin rates.* Users would still need to input insulin doses to account for meals. A study that followed 124 diabetic participants using the Medtronic device wrapped up in May and showed that the system was safe and could be trusted to autonomously determine doses.

2. One of the largest clinical trials so far kicked off at the start of this year with 240 patients based throughout the U.S. and Europe. Led by researchers at the University of Virginia and Harvard University, along with a consortium of organizations, the trial will test the safety and effectiveness of a system that integrates an insulin pump, a continuous glucose monitor and a smartphone. The smartphone relies on an algorithm to analyze blood sugar readings and then instructs the pump …

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